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| 烯烃1,2-膦官能团化反应研究进展 |
| Research Progress on 1,2-Phosphine Functionalization of Alkenes |
| 投稿时间：2025-11-15 修订日期：2025-12-10 |
| DOI： |
| 中文关键词: 烯烃 1,2-双官能团化 ??碳-磷键构建 区域选择性 研究进展 |
| 英文关键词:Alkenes, 1,2-Difunctionalization, C-P bond formation, Regioselectivity, Research progress |
| 基金项目:国家自然科学基金项目（22071113），天津市自然科学基金面上项目(24JCYBJC01960) |
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| 中文摘要: |
| 烯烃1,2-双官能团化反应是有机合成中从烯烃直接构建C-X (X = C, N, O…)键的重要策略,其优点包括良好的区域选择性、步骤经济性和原子经济性,符合绿色化学的发展要求。有机膦化合物在医药、农药、材料科学及配体化学等领域具有重要价值,因此发展简单高效构建碳-磷键的合成方法受到广泛关注。本文综述了在构建碳-磷键的同时,构建碳-碳键、碳-氮键、碳-硫键、碳-氧键和碳-卤键的反应研究进展,并对该领域的未来发展方向进行了展望。 |
| 英文摘要: |
| The 1,2-difunctionalization of alkenes represents a significant strategy in organic synthesis for the direct construction of C-X (X = C, N, O…) bonds from alkenes. This approach offers advantages including good regioselectivity, step economy, and atom economy, aligning with the principles of green chemistry. Organophosphorus compounds hold substantial value in diverse fields such as pharmaceuticals, agrochemicals, materials science, and ligand chemistry. Consequently, the development of simple and efficient synthetic methods for carbon-phosphorus (C-P) bond formation has garnered widespread attention. This review summarizes the research progress in reactions that simultaneously construct C-P bonds alongside C-C, C-N, C-S, C-O, and C-halogen bonds. Furthermore, future development directions in this field are also discussed. |
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