| 朱东建,王彪,任爱山.化学通报,2025,88(11):1201-1207. |
| 基于萘杂香豆素的硫化氢荧光探针构建及其性能研究 |
| Construction and performance study of hydrogen sulfide fluorescent probe based on naphthalene hybrid coumarin |
| 投稿时间：2025-06-13 修订日期：2025-07-03 |
| DOI： |
| 中文关键词: 萘杂香豆素 硫化氢 荧光探针 |
| 英文关键词:Naphthalene hybrid coumarin Hydrogen sulfide Fluorescent probe |
| 基金项目:国家自然科学基金项目(21765008)和广西自然科学基金项目(2024GXNSFAA010380,2021GXNSFBA220038,2019GXNSFDA185003)资助 |
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| 中文摘要: |
| 以6-溴-2-萘酚和7-羟基香豆素为原料，首次合成了萘杂香豆素荧光团2，将其与2,4-二硝基氟苯反应构建了一种新型硫化氢荧光探针1。通过核磁共振氢谱、核磁共振碳谱和质谱表征其结构，并采用吸收光谱和荧光光谱研究了其对硫化氢的识别性能。荧光探针1本身无荧光，当对硫化氢进行识别时，由于2,4-二硝基苯醚裂解释放出萘杂香豆素荧光团2，荧光显著增强。研究结果表明，荧光探针1对硫化氢识别具有响应迅速（4 min）、灵敏度高（检出限为16.8 nmol/L）、选择性好、不受其他分析物干扰等优点，而且可通过在日光下从无色变为浅黄色和在365 nm紫外灯下从无色变为绿色的颜色变化快速简便检测硫化氢。 |
| 英文摘要: |
| The fluorophore of naphthalene hybrid coumarin 2 was synthesized for the first time using 6-bromo-2-naphthol and 7-hydroxycoumarin as raw materials. Then, it was reacted with 2,4-dinitrofluorobenzene to construct a novel fluorescent probe 1 for hydrogen sulfide. The structure of fluorescent probe 1 was characterized by 1H NMR, 13C NMR and MS. The recognition performance of fluorescent probe 1 towards hydrogen sulfide was investigated by absorption and fluorescence spectra. Fluorescent probe 1 itself had no fluorescence. When it recognized hydrogen sulfide, the fluorescence emission was significantly enhanced due to the release of naphthalene hybrid coumarin 2 via the cleavage of 2,4-dinitrophenyl ether. The results indicated that fluorescent probe 1 can detect hydrogen sulfide with the advantages of rapid response (4 min), high sensitivity (detection limit of 16.8 nmol/L), good selectivity and no interference from other analytes. Moreover, fluorescent probe 1 can quickly and simply recognize hydrogen sulfide by the color change from colorless to pale yellow under daylight and from colorless to green under 365 nm UV light. |
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