| 周子诣,王思昀,胡依琳,洪明哲,章昱然,赵一凡,郦勇,葛盼瑜,程凯.化学通报,2025,88(10):1075-1090. |
| 自由基脱羧Giese反应在天然产物全合成中的应用研究进展 |
| Research Progress on the Application of Radical Decarboxylative Giese Reaction in Total Synthesis of Natural Products |
| 投稿时间：2025-04-21 修订日期：2025-06-02 |
| DOI： |
| 中文关键词: 自由基脱羧反应 分子内脱羧环化 分子间脱羧环化 天然产物全合成 |
| 英文关键词:Giese reaction radical decarboxylation, intramolecular decarboxylative cyclization, intermolecular decarboxylative cyclization, total synthesis of natural products |
| 基金项目:国家自然科学基金项目(21402123)、浙江省自然科学基金项目(LY18B020006)、2024 年浙江省大学生科技创新活动计划(新苗人才 计划)项目(2024R431A012)和2025 年国家级大学生创新创业训练计划项目资助 |
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| 中文摘要: |
| 近年来，自由基脱羧Giese反应因其在构建碳-碳及碳-卤键中的高效性与可靠性而备受关注，并已被广泛应用于复杂天然产物的全合成，涵盖分子间及分子内过程。然而，针对其在全合成领域应用的系统性总结仍较匮乏。本文重点综述了该类反应的引发策略及其在多环天然产物合成中的应用，并系统梳理了1971年至2023年间NHPI活性酯参与的自由基脱羧反应研究进展。 |
| 英文摘要: |
| In recent years, radical decarboxylative Giese reactions have garnered significant attention due to their high efficiency and reliability in constructing carbon-carbon (C-C) and carbon-halogen (C-X) bonds. Both intermolecular and intramolecular radical decarboxylative reactions have been widely applied in the total synthesis of natural products. However, research papers on the application of radical decarboxylative Giese reactions in total synthesis have not been summarized and classified yet. This review focuses on the initiation strategies for radical decarboxylation reactions, particularly their application in the synthesis of polycyclic natural products. It also systematically summarizes the progress of N-hydroxyphthalimide (NHPI) ester-mediated radical decarboxylation from 1971 to 2023. |
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