| 秦婷,莫丽,陈平平,安雪婕,陈治明.化学通报,2020,83(7):665-671. |
| 联萘酚多氢键硫脲催化合成1,4-二氢吡啶衍生物 |
| Syntheses of 1,4-Dihydropyridine Derivatives Catalyzed by BINOL Multi-Hydrogen Bonded Thiourea |
| 投稿时间：2020-01-12 修订日期：2020-02-25 |
| DOI： |
| 中文关键词: 催化剂 1,4-二氢吡啶 硫脲 合成 |
| 英文关键词:Catalyst 1,4-Dihydropyridine Thiourea Synthesis |
| 基金项目:国家自然科学基金项目（21362006）资助 |
|
| 摘要点击次数: 1363 |
| 全文下载次数: 857 |
| 中文摘要: |
| 本文合成了三种具有多氢键的联萘酚轴手性硫脲催化剂，并将其用于催化合成1，4-二氢吡啶衍生物。结果显示，所合成的新型多氢键硫脲均表现出较好的催化作用，能有效地提高1，4-二氢吡啶衍生物的收率和对映选择性。所有新化合物结构均经过1H NMR、13C NMR、IR、熔点等表征所确认。 |
| 英文摘要: |
| Three kinds of structure-symmetric thiourea catalysts containing multi-hydrogen bond with binol axial chiral were synthesized and successfully applied to the syntheses of 1,4-dihydropyridine derivatives. The results showed that the synthesized polyhydrogen-bonded thioureas have better catalytic activity, which can effectively improve the yield and enantioselectivity of the 1,4-dihydropyridine derivatives. All new compounds were characterized by 1H NMR、13C NMR、IR、melting point and so on. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
京公网安备11010802047317号