| 何姗,任会静,曹云云.化学通报,2014,77(8):751. |
| 盐酸瑞伐拉赞及其关键中间体的合成研究进展 |
| Research Progress in the Synthesis of Revaprazan hydrochloride and its key intermediates |
| 投稿时间：2014-02-14 修订日期：2014-04-08 |
| DOI： |
| 中文关键词: 盐酸瑞伐拉赞 1-甲基-1,2,3,4-四氢异喹啉 合成综述 |
| 英文关键词:Revaprazan hydrochloride 1-methyl-1, 2, 3, 4-tetrahydroisoquinoline synthesis review |
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| 中文摘要: |
| 盐酸瑞伐拉赞是已经上市的新型可逆型质子泵抑制剂，合成过程中用到了昂贵的关键中间体1-甲基-1，2，3，4-四氢异喹啉，本文综述了关键中间体和盐酸瑞伐拉赞的各种合成方法，并讨论了各种方法的优缺点。 |
| 英文摘要: |
| Revaprazan hydrochloride is a new reversible proton pump inhibition which has been on the market,The expensive 1-methyl-1, 2, 3, 4-tetrahydroisoquinoline as key intermediate is used in the synthesis process. This paper reviewed the synthetic methods of intermediates and revaprazan hydrochloride and discussed the disadvantages and advantages of various methods. |
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