表面增强拉曼散射技术在氧化应激标志物检测中的研究进展

曾茹颖; 罗芯蕊; 张佳; 黄路; 刘潜

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表面增强拉曼散射技术在氧化应激标志物检测中的研究进展

Research Progress in Surface-Enhanced Raman Scattering for the Detection of Oxidative Stress Biomarkers

投稿时间：2026-05-25 修订日期：2026-06-14

DOI：

中文关键词: 表面增强拉曼散射氧化应激标志物生物传感器活性基底

英文关键词:Surface-enhanced Raman scattering Oxidative stress Biomarkers Biosensors Active substrates

基金项目:全国重点实验室自主部署重点研发计划项目（20243BCC31008）、校级博士科研启动项目（2023BSZR030）

作者	单位	邮编
曾茹颖	江西中医药大学中医学院中西医结合一级学科中西医结合儿童健康研究院　南昌　330004	330004
罗芯蕊	江西中医药大学中医学院中西医结合一级学科中西医结合儿童健康研究院　南昌　330004
张佳	江西中医药大学中医学院中西医结合一级学科中西医结合儿童健康研究院　南昌　330004
黄路	江西中医药大学中医学院中西医结合一级学科中西医结合儿童健康研究院　南昌　330004
刘潜^*	江西中医药大学中医学院中西医结合一级学科中西医结合儿童健康研究院　南昌　330004	330004

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中文摘要:

氧化应激是机体活性氧（Reactive Oxygen Species, ROS）产生与清除失衡导致的病理生理状态，与肿瘤、神经退行性疾病、心血管疾病等多种疾病的发生发展密切相关。氧化应激标志物的精准、灵敏检测对疾病早期诊断、病情监测及机制研究具有重要意义。表面增强拉曼散射（Surface-Enhanced Raman Scattering, SERS）技术凭借高灵敏度、高分辨率、无损检测及可提供分子结构信息等独特优势，已成为氧化应激标志物检测的重要手段。本文系统梳理了氧化应激主要标志物的分类及检测挑战，总结了SERS检测中活性基底的类型、信号增强策略，重点阐述了不同氧化应激标志物的SERS检测方法，分析了当前研究存在的问题，并对未来发展趋势进行展望，为SERS技术在氧化应激相关领域的深入研究与实际应用提供参考。

英文摘要:

Oxidative stress is a pathophysiological state caused by an imbalance between the production and elimination of reactive oxygen species (ROS), and is closely associated with the occurrence and progression of various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. Accurate and sensitive detection of oxidative stress biomarkers is of great significance for early disease diagnosis, disease monitoring, and mechanistic studies. Surface-enhanced Raman scattering (SERS), owing to its unique advantages such as high sensitivity, high resolution, non-destructive detection, and the ability to provide molecular structural information, has become an important technique for detecting oxidative stress biomarkers. This review systematically summarizes the classification of major oxidative stress biomarkers and the challenges associated with their detection. It further discusses the types of active substrates and signal enhancement strategies used in SERS detection, with a particular focus on SERS-based detection methods for different oxidative stress biomarkers. In addition, the current limitations in this field are analyzed, and future development trends are discussed. This review aims to provide a reference for further research and practical applications of SERS technology in oxidative stress-related fields.

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